The ‘off-label’ prescription of antidepressants to treat conditions for which they are not approved is on the rise. A nearly 10 year long McGill study, including 100,000+ prescriptions, has found that 29% of prescriptions are for off-label use. "Off-label' uses included insomnia, pain, & ADD/ADHD.
Effect of Formula Containing Lactobacillus Reuteri DSM 17938 on Fecal Microbiota of Infants Born by Cesarean-Section.
Rodenas CL, et al. J Pediatr Gastroenterol Nutr. 2016.
OBJECTIVES: Microbiota modulation by probiotics in infants born by cesarean (C)-section is poorly understood. We aimed at assessing the response of C-section-delivered infant microbiota to a formula containing L. reuteri DSM 17938 and comparing it with that of vaginally-delivered infants.
METHODS: Infants delivered by C-section (C) and vaginally (V) were randomized to receive either control formula (CCt, n = 10; VCt, n = 10) or the same formula containing L. reuteri (CLr, n = 11; VLr, n = 9) within 72 hours following birth. Stool samples were collected at 2 weeks and 4 months of age. Microbial DNA was extracted, amplified and pyrosequenced.
RESULTS: The phylogenetic profiles of the CLr, VCt and VLr microbiota were not significantly different at any age, but diverged from that of CCt at 2 weeks. Compared with VCt, CCt displayed lower Bifidobacterium and higher Enterobacter, unclassified Enterobacteriaceae, Enterococcus, Clostridium and unclassified Clostridiaceae relative abundance at 2 weeks, as well as lower Collinsella and higher Enterococcus and Coprococcus abundance at 4 months. The level of most of these taxa was not significantly different between the CLr and the vaginal-delivery groups. Compared with VCt, the only difference observed in VLr microbiota was higher Lactobacillus at the 2 study ages and Coprococcus at 4 months.
CONCLUSIONS: Our results show that a formula containing L. reuteri DSM 17938 does not essentially alter the microbiota in vaginally-born infants. However, in C-section delivered infants this strain seems to play the role of keystone species by modulating the early development of the microbiota towards the composition found after vaginal delivery.
27035371 [PubMed - as supplied by publisher]